Bioregulator Peptides: Fact Or Fiction?

Written by Johnathon Anderson, Ph.D., a research scientist specializing in regenerative medicine and serving as an Associate Professor at the University of California Davis School of Medicine

What Are Bioregulator Peptides?

Bioregulator peptides are peptides that bind to intracellular proteins that attach to specific DNA sequences associated with genes, and purportedly regulate gene expression in the process. This term was coined by Russian scientists at Tbilisi State University.

Is "Bioregulator Peptide" A Term Used By the Scientific Community?

The term "bioregulator peptide" is not widely used by other scientists working in this field but has been popularized in discussion forums associated with peptide research. The term devoid of a meaningful definition accepted by our scientists in the field. Most of the studies are not available online as they have been published in low quality journals. Of the studies this group has published on this subject matter, the data, experimental design, and overall quality of scientific rigor is severely lacking.

The authors claim the following properties of bioregulator peptides:

1. Intercellular Signaling

   Bioregulator peptides act as signaling factors, transporting information to cells and tissues. They are purported to play a role in regulating gene expression and metabolism.

2. Maintaining Homeostasis

   These peptides help maintain homeostasis in cells’ microenvironment.

3. Adaptive Responses

   Bioregulator peptides modulate adaptive responses to various stimuli. They may potentiate cellular processes or modulate metabolic pathways.

4. Aging

   Some bioregulator peptides are studied for their potential to support cellular repair and regeneration which typically declines with the aging process.

5. Therapeutic Potential

   These Russian researchers claim that bioregulator peptides may have potential therapeutic applications for anti-aging and longevity.

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References

V Kh Khavinson, B I Kuznik, G A Ryzhak “Peptide bioregulators: the new class of geroprotectors” Adv Gerontol 2013;26(1):20-37 https://pubmed.ncbi.nlm.nih.gov/24003726/

V Kh Khavinson, B I Kuznik, G A Ryzhak “Peptide bioregulators: the new class of geroprotectors” Adv Gerontol. 2012;25(4):696-708. https://pubmed.ncbi.nlm.nih.gov/23734519/

V N Anisimov, V Kh Khavinson “The use of peptide bioregulators for cancer prevention” Vopr Onkol. 2009;55(3):291-304 https://pubmed.ncbi.nlm.nih.gov/19670728/

T Lezhava, J Monaselidze, T Kadotani, N Dvalishvili, T Buadze “Anti-aging peptide bioregulators induce reactivation of chromatin” Georgian Med News. 2006 Apr:(133):111-5 https://pubmed.ncbi.nlm.nih.gov/16705247/

Teimuraz Lezhava, Vladimir Khavison, Jamlet Monaselidze, Tinatin Jokhadze, Nana Dvalishvili, Nino Bablishvili, Shota Barbakadze “Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people” Biogerontology. 2004;5(2):73-9 https://link.springer.com/article/10.1023/B:BGEN.0000025070.90330.7f