Ipamorelin + CJC-1295 (no DAC)

Certificate of Analysis (COA) data available in product photos.

Purity: ≥ 99 % (HPLC verified)
Sterility: Confirmed (sterile-filtered)
Endotoxins (LPS): Not detected
Trifluoroacetic Acid (TFA): Not detected (LC-MS verified)
Identity: Confirmed (LC-MS verified)
Quantity: Verified (HPLC analysis)

Format: Lyophilized powder sealed in an airtight vial. Lyophilization enhances stability during storage.

Pricing

Quantity	Price/Vial	Savings
1 vial	$103	—
2 vials	$99	Save 4 %
3 vials	$95	Save 8 %
4 vials	$91	Save 12 %
5 vials	$87	Save 16 %

Product Overview

Ipamorelin

Ipamorelin is a pentapeptide secretagogue (Aib-His-D-2-Nal-D-Phe-Lys) that acts as a selective growth hormone–releasing peptide (GHRP). It binds to the ghrelin receptor (GHS-R1a) to promote GH release in pituitary cultures while showing minimal interaction with other endocrine axes (ACTH, FSH, LH, TSH, or cortisol).

Molecular Formula: C₃₈H₄₉N₉O₅
Molecular Weight: 711.85 g/mol
PubChem CID: 9831659

CJC-1295 (no DAC) / mod GRF 1-29

CJC-1295 (no DAC) is a growth hormone–releasing hormone (GHRH) analog derived from the first 29 amino acids of native GHRH. The “no DAC” form lacks the drug-affinity complex, making it ideal for studying short-acting, physiologic GH pulses. Originally developed by ConjuChem Biotechnologies, it has been widely used to model pituitary regulation and GH/IGF-1 signaling.

Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3367.95 g/mol
PubChem CID: 91976842

Biological Background (For Research Context Only)

The Ipamorelin + CJC-1295 (no DAC) combination is used in research exploring the synergistic activity between ghrelin-receptor agonists (GHRPs) and GHRH analogs. Together, these compounds serve as models for studying growth hormone pulse generation, feedback regulation, and downstream IGF-1 expression in the liver and peripheral tissues.

Key experimental findings include:

Increased GH pulse amplitude and frequency in preclinical endocrine models.
Maintenance of physiological feedback loops, enabling study of natural GH rhythm.
Activation of cAMP-PKA and PLC signaling cascades involved in secretagogue responses.

All data are derived from non-clinical studies; no conclusions should be drawn regarding human use.

Physiological Context of GH / IGF-1 Signaling (For Research Reference)

In scientific literature, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are recognized for their wide-ranging roles in cellular metabolism and tissue maintenance:

Skeletal and connective tissue:
Promotes collagen synthesis and matrix turnover in bone and cartilage models.
Muscle physiology:
Supports protein synthesis and myocyte differentiation in culture systems.
Adipose and metabolic research:
Regulates lipolytic and glucose-handling pathways under endocrine control.
Skin and wound-model systems:
Stimulates fibroblast proliferation and angiogenic signaling in vitro.
Neural and cognitive studies:
Influences neurotrophic factor expression and synaptic plasticity pathways.
Hepatic and systemic regulation:
Coordinates IGF-1 synthesis in hepatocytes, modulating systemic feedback to the pituitary.

Alternate Names

CJC-1295 (no DAC): mod GRF 1-29
Ipamorelin: Growth hormone–releasing pentapeptide

Storage & Handling

Store at 4 °C in a dry, light-protected environment for medium-term storage. Reconstitute with sterile, bacteriostatic solvent immediately before use. Proper storage maintains peptide integrity. Lyophilized IPA/CJC can be stored at 4 °C for months, while reconstituted IPA/CJC needs to be used within 3-4 weeks while stored at 4 °C.

Intended Use and Compliance

All peptide products from Peptide Systems are supplied for laboratory and scientific research use only. They are not FDA-approved and not intended for human or veterinary use. Purchasers must agree to all Terms and Conditions before ordering.

References & Further Reading

Ipamorelin selectivity – https://pubmed.ncbi.nlm.nih.gov/9849822/
CJC-1295 (no DAC) pharmacodynamics – https://pubmed.ncbi.nlm.nih.gov/16352683/
GHRH and GHRP synergy review – https://pubmed.ncbi.nlm.nih.gov/33776931/
IGF-1 signaling overview – https://pubmed.ncbi.nlm.nih.gov/39638246/

Ipa + CJC

Name: Ipa + CJC
Brand: Peptide Systems
SKU: PS-IPA+CJC-10mg

SKU: PS-IPA+CJC-10mg

$103.00

Buy 5 vials get 16% off

Quantity

CERTIFIED by 3rd party, US registered labs with ISO 17025:2017 certification

Certified sterile.

Certified free of microbial contaminants (endotoxin, LPS, LAL).

Certified free of chemical contaminants (TFA, IEX).

Certified peptide identity (HPLC, LC-MS).

Certified >99% pure (HPLC).
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Due to regulations regarding the sale of our products, returns are prohibited. However, in the rare event that the order is shipped incorrectly or the items received are not the items ordered, please contact us by email, support@peptidesystems. We will issue a replacement of your original order.

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Due to our rigorous quality control standards and the fragile nature of our products, we cannot accept returns. On the rare occasion that your order arrives with missing, incorrect, or damaged items, please email support@peptidesystems.com for assistance.

Our customer support representatives are standing by to ensure that our customers are 100% satisfied with our product quality, customer support, and delivery. Cancellations must be requested by email before the order has been shipped. Once the order has shipped, you may not cancel it.

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In the unfortunate event that the carrier (e.g., USPS, UPS) loses the shipment, and it is not recovered with a non-delivery confirmation, we will reship the order at no additional cost to the customer. However, if the carrier (e.g., USPS) claims the shipment as “delivered” in the delivery confirmation, our guarantee has been fulfilled, and we will not reship free of charge.
This product is sold as a pure compound for research purposes only. This product is intended for laboratory IN-VITRO RESEARCH PURPOSES ONLY-- NOT FOR HUMAN or ANIMAL USE or CONSUMPTION of any kind and are not to be used for any other purposes, including but not limited to food and/or drugs, medical devices, vitro diagnostic purpose, or for commercial purposes. The purchaser agrees that the products have not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use.

Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.
1.   Taaffe, DR et al. Lack of effect of GH on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. https://pubmed.ncbi.nlm.nih.gov/8550787/
2.   Welle, S, et al. GH increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. https://academic.oup.com/jcem/article/81/9/3239/2651047?login=false
3.   Rudman, D et al. Effects of GH in Men over 60 Years Old. https://www.nejm.org/doi/full/10.1056/NEJM199007053230101
4.   Nass, R et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/5.   Giannoulis, MG et al. The Effects of GH and/or Testosterone in Healthy Elderly Men: A Randomized Controlled Trial. https://academic.oup.com/jcem/article/91/2/477/2843327?login=false
6.   Blackman, MR et al. GH and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial. https://jamanetwork.com/journals/jama/fullarticle/1108358
7. Brill, KT et al. Single and Combined Effects of GH and Testosterone Administration on Measures of Body Composition, Physical Performance, Mood, Sexual Function, Bone Turnover, and Muscle Gene Expression in Healthy Older Men. https://pubmed.ncbi.nlm.nih.gov/12466367/
8.   Lange, KHW et al. GH Administration Changes Myosin Heavy Chain Isoforms in Skeletal Muscle But Does Not Augment Muscle Strength or Hypertrophy, Either Alone or Combined with Resistance Exercise Training in Healthy Elderly Men. https://academic.oup.com/jcem/article/87/2/513/2846630
9.   Yarasheski, K et al. Effect of GH and resistance exercise on muscle growth and strength in older men. https://pubmed.ncbi.nlm.nih.gov/7525633/
10.   Al-Samerria, S et al. Exploring the Therapeutic Potential of Targeting GH and IGF-1 in the Management of Obesity: Insights from the Interplay between These Hormones and Metabolism. https://www.mdpi.com/1422-0067/24/11/9556
11.   Generali, JA et al. Recombinant GH: HIV-Related Lipodystrophy. https://journals.sagepub.com/doi/10.1310/hpj4905-432
12.   Adrian, S et al. The GHRH Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. https://link.springer.com/article/10.14283/jfa.2018.45
13.   Kopchick, JJ et al. The effects of GH on adipose tissue: old observations, new mechanisms. https://www.nature.com/articles/s41574-019-0280-9
14.   Siemensma, EPC et al. Beneficial Effects of GH Treatment on Cognition in Children with Prader-Willi Syndrome: A Randomized Controlled Trial and Longitudinal Study. https://academic.oup.com/jcem/article/97/7/2307/2834113
15.   Stephen, MD et al. Health-related quality of life and cognitive functioning in pediatric short stature: Comparison of GH-naïve, GH-treated, and healthy samples. https://pubmed.ncbi.nlm.nih.gov/20886355/
16.   Baker, LD et al. Effects of GHRRH on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults: Results of a Controlled Trial. https://jamanetwork.com/journals/jamaneurology/fullarticle/1306261
17.   Deijen, JB et al. Cognitive changes during GH replacement in adult men. https://pubmed.ncbi.nlm.nih.gov/9618751/
18.   Maric, NP et al. Psychiatric and neuropsychological changes in GH-deficient patients after traumatic brain injury in response to GH therapy. https://link.springer.com/article/10.1007/BF03350340
19.   Johansson, JO et al. Treatment of GH-Deficient Adults with GH Increases the Concentration of Growth Hormone in the Cerebrospinal Fluid and Affects Neurotransmitters. https://pubmed.ncbi.nlm.nih.gov/7537355/
20.   Lai, Z et al. Age-related reduction of GH-binding sites in the human brain. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027725/
21.   Pathipati, P et al. GH and prolactin regulate human neural stem cell regenerative activity. https://pubmed.ncbi.nlm.nih.gov/21664953/
22.   Chung, JY et al. The protective effect of GH on Cu/Zn superoxide dismutase-mutant motor neurons. https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-015-0140-z
23.   Longobardi, S et al. GH Effects on Bone and Collagen Turnover in Healthy Adults and Its Potential as a Marker of GH Abuse in Sports: A Double Blind, Placebo-Controlled Study. https://pubmed.ncbi.nlm.nih.gov/10770189/
24.   Nelson, AE et al. Pharmacodynamics of GH Abuse Biomarkers and the Influence of Gender and Testosterone: A Randomized Double-Blind Placebo-Controlled Study in Young Recreational Athletes. https://pubmed.ncbi.nlm.nih.gov/18381573/
25.   Doessing, S et al. GH stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. https://pubmed.ncbi.nlm.nih.gov/19933753/
26.   Holt, RIG et al. The Use and Abuse of GH in Sports. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116101/
27.   Khatri, M et al. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review. https://pubmed.ncbi.nlm.nih.gov/34491424/
28.   Lee, J et al. Collagen supplementation augments changes in patellar tendon properties in female soccer players. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1089971/full
29.   Edmondson, SR et al. Epidermal Homeostasis: The Role of the GH and Insulin-Like Growth Factor Systems. Endocr Rev 24, 737–764 (2003).
30.   Recombinant GH Accelerates Wound Healing i... : Annals of Surgery. https://journals.lww.com/annalsofsurgery/abstract/1994/07000/recombinant_human_growth_hormone_accelerates_wound.4.aspx.
31.   Jørgensen, PH et al. Dose-response study of the effect of GH on mechanical properties of skin graft wounds. https://linkinghub.elsevier.com/retrieve/pii/S0022-4804(85)71046-3
32. Kim, SH et al. The Effect of Topically Applied GH on Wound Healing in Pigs https://pubmed.ncbi.nlm.nih.gov/25903440/
33.   Cristóbal, L et al. Local GH Therapy for Pressure Ulcer Healing on a Human Skin Mouse Model. https://pubmed.ncbi.nlm.nih.gov/31454882/
34.   Dioufa, N et al. Acceleration of wound healing by GHRH and its agonists. https://www.pnas.org/doi/full/10.1073/pnas.1013942107
35.   Kerkhofs, M et al. Sleep-promoting effects of GHRH in normal men. https://pubmed.ncbi.nlm.nih.gov/8476038/
36.   Perras, B et al. Sleep and endocrine changes after intranasal administration of GHRH in young and aged humans. https://pubmed.ncbi.nlm.nih.gov/10451909/
37.   Copinschi, G et al. Prolonged Oral Treatment with MK-677, a Novel GH Secretagogue, Improves Sleep Quality in Man. https://karger.com/nen/article-abstract/66/4/278/224995/Prolonged-Oral-Treatment-with-MK-677-a-Novel?redirectedFrom=fulltext
38.   Kluge, M et al. Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males. https://www.sciencedirect.com/science/article/abs/pii/S0306453008000292

39. Beck, DE et al. “Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients” Int J Colorectal Dis 2014 https://pubmed.ncbi.nlm.nih.gov/25331030/
Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.
The above article was researched, edited, and written by Dr. Johnathon Anderson, PhD who holds a doctorate degree from the University of California Davis.

Dr. David E. Beck, MD, is one of the co-authors of “Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic Ipamorelin for the management of postoperative ileus in bowel resection patients.” He completed his general surgery residency at Wilford Hall USAF Medical Center at Lackland AFB, Texas. After spending a year as an Air Force general surgeon at a small base in Florida, he completed a fellowship in Colon and Rectal Surgery at the Cleveland Clinic. Dr. Beck then returned to Wilford Hall to serve as the Chief of Colon and Rectal Surgery and eventually as Chairman of the Department of General Surgery. During his Air Force career, he served as the Air Force Surgeon General's consultant in Colon and Rectal Surgery, and during the Gulf War, he served as Chief of Surgery at the 81 Contingency Hospital located at Little Rissington, United Kingdom. In 1993, he joined the colorectal staff at the Ochsner Clinic and in 1995 became chairman of the department. In 2005, he was elected to the Board of Governors of the Ochsner Clinic. Has been in practice 38 years and is experienced in colonoscopy, anorectal surgery, and diseases of the colon.

Dr. Beck is being referenced as one of th

e leading research scientists in the research and development of the Ipamorelin peptide. He is in no way endorsing or advocating for the purchase, sale, or use of this product for any reason. There is no relationship, implied or otherwise, between Peptide Systems and this doctor. The purpose of citing this doctor is to acknowledge, recognize and credit the extensive research he has performed in this area over the years. He is listed under reference 39.
All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease. Peptide Systems is a chemical supplier. Peptide Systems is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Peptide Systems is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act.

Ipa + CJC

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