Selank
Certificate of Analysis (COA) data available in product photos.
Purity: ≥ 99 % (HPLC verified)
Sterility: Confirmed (sterile-filtered)
Endotoxins (LPS): Not Detected
Trifluoroacetic Acid (TFA): Not Detected (LC-MS verified)
Identity: Confirmed (LC-MS verified)
Quantity: Verified (HPLC analysis)
Format: Lyophilized powder sealed in an airtight vial. Lyophilization enhances peptide stability during storage.
Pricing
| Quantity | Price/Vial | Savings |
|---|---|---|
| 1 vial | $65 | — |
| 2 vials | $62 | Save 4 % |
| 3 vials | $60 | Save 8 % |
| 4 vials | $57 | Save 12 % |
| 5 vials | $54 | Save 16 % |
Product Overview
Selank is a synthetic heptapeptide (seven amino acids) with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It was originally developed as an analog of tuftsin, a naturally occurring immunomodulatory peptide fragment derived from human immunoglobulin G (IgG). Tuftsin and its analogs have been studied for their roles in immune regulation and neural signaling.
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: 751.9 g/mol
PubChem CID: 11765600
Alternate Names: TP-7, Selanc, 129954-34-3
Biological Background (For Research Context Only)
Origin and Structural Features
Selank was designed to combine the immunoregulatory sequence of tuftsin with a Pro-Gly-Pro (PGP) motif, which is believed to enhance stability and transport within the central nervous system (CNS) in experimental models. The peptide has been used in research exploring neurotransmitter modulation, gene expression, and immune–neural interactions.
Molecular Pathways Studied
1. Neurotrophic Signaling (BDNF)
Preclinical research suggests that Selank can influence the expression of brain-derived neurotrophic factor (BDNF), a protein that supports neuronal growth and synaptic plasticity. Studies in rodent hippocampal tissue have observed altered BDNF mRNA expression following exposure to Selank, indicating possible transcriptional modulation relevant to neural adaptation mechanisms.
2. Serotonin System Regulation
Experimental data using murine models have shown that Selank may modulate serotonin receptor gene expression and related signaling pathways. Serotonergic activity plays an important role in regulating neuronal tone, and Selank’s effects in these studies have been primarily analyzed at the molecular transcriptional level.
3. GABAergic Modulation
Gene-expression profiling in cultured neurons demonstrated that Selank can influence GABA (gamma-aminobutyric acid) signaling components. Out of 84 neurotransmission-related genes examined in one study, Selank altered transcription patterns associated with GABA receptor subunits, suggesting potential involvement in inhibitory synaptic regulation.
Immune System Research
Given its origin from tuftsin, Selank has also been investigated for its ability to affect cytokine production and immune cell communication in preclinical systems. These studies contribute to understanding how immune and neural signaling networks intersect at the peptide level.
Research Applications
Selank is widely used in neurobiology, psychoneuroimmunology, and molecular neuroscience research. Laboratory investigations focus on:
Neural gene expression related to BDNF, GABA, and serotonin pathways.
Cross-talk between immune and nervous systems.
Peptide–receptor signaling and peptide transport across biological membranes.
Stability and bioavailability of short neuroactive peptides in CNS models.
Storage & Handling
Store at 4 °C in a dry, light-protected environment for medium-term storage. Reconstitute with sterile, bacteriostatic solvent immediately before use. Proper storage maintains peptide integrity. Lyophilized Selank can be stored at 4 °C for months, while reconstituted Selank needs to be used within 4-7 days while stored at 4 °C.
Intended Use and Compliance
All peptide products from Peptide Systems are supplied for laboratory and scientific research use only. They are not FDA-approved and not intended for human or veterinary consumption.
Purchase implies agreement to our full Terms and Conditions regarding permitted research use.
References & Further Reading
Selank and BDNF expression in hippocampus - https://pubmed.ncbi.nlm.nih.gov/31625062/
Tuftsin analogs and neuroactive mechanisms - https://pmc.ncbi.nlm.nih.gov/articles/PMC3805743/
GABAergic modulation by Selank - https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2016.00031/full
Enkephalin pathway interactions - https://pmc.ncbi.nlm.nih.gov/articles/PMC6707067/
Selank
Buy 5 vials get 16% off
CERTIFIED by 3rd party, US registered labs with ISO 17025:2017 certification
- Certified sterile.
- Certified free of microbial contaminants (endotoxin, LPS, LAL).
- Certified free of chemical contaminants (TFA, IEX).
- Certified peptide identity (HPLC, LC-MS).
- Certified >99% pure (HPLC).
