Semax
Certificate of Analysis (COA) data available in product photos.
Purity: ≥ 99 % (HPLC verified)
Sterility: Confirmed (sterile-filtered)
Endotoxins (LPS): Not Detected
Trifluoroacetic Acid (TFA): Not Detected (LC-MS verified)
Identity: Confirmed (LC-MS verified)
Quantity: Verified (HPLC analysis)
Format: Lyophilized powder sealed in an airtight vial. Lyophilization enhances peptide stability during long-term storage.
Pricing
| Quantity | Price/Vial | Savings |
|---|---|---|
| 1 vial | $65 | — |
| 2 vials | $62 | Save 4 % |
| 3 vials | $60 | Save 8 % |
| 4 vials | $57 | Save 12 % |
| 5 vials | $54 | Save 16 % |
Product Overview
Semax is a synthetic heptapeptide derived from the fragment Met-Glu-His-Phe-Pro-Gly-Pro, corresponding to ACTH (4-7) with an added Pro-Gly-Pro extension to enhance structural stability.
Originally developed as a short fragment analog of adrenocorticotropic hormone (ACTH), Semax has been used in research to explore neurotrophic signaling, stress-response pathways, and gene expression modulation in the central nervous system (CNS).
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.9 g/mol
PubChem CID: 9811102
Alternate Names: ACTH(4-7), MEHFPGP
Biological Background (For Research Context Only)
Origin and Design
Semax was engineered to isolate specific neuromodulatory regions of ACTH without affecting corticosteroid secretion. It is widely used in neuroscience and molecular biology research to examine peptide-mediated signaling, neuroplasticity, and transcriptional regulation in neuronal tissues.
Molecular Pathways Studied
1. Neurotrophic Factors (BDNF & NGF)
Laboratory studies indicate that Semax can influence the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) genes in cortical and hippocampal tissues.
These neurotrophins are central to neuronal survival, synaptic remodeling, and cognitive processes in model systems.
2. Neurotransmitter Regulation
Preclinical data suggest that Semax affects monoaminergic signaling, including dopaminergic and serotonergic pathways, helping to elucidate peptide involvement in neurotransmitter release and receptor regulation.
3. Hypoxia and Ischemia Models
In experimental models of cerebral hypoxia, Semax exposure has been associated with modulation of oxidative-stress response genes and antioxidant enzyme expression, supporting its study as a molecular probe for cellular resilience under oxygen deprivation.
4. Gene-Expression and Neural Network Activity
Semax has been shown to alter gene-expression profiles in the hippocampus and prefrontal cortex, regions critical for memory and cognitive function. Functional imaging studies in animal models have suggested modulation of default-mode-network activity, providing insight into peptide-based neuroregulation.
Mechanistic Insights (For Research Reference)
Acts through melanocortin receptor–independent pathways distinct from full-length ACTH.
Influences cAMP and CREB signaling, which regulate transcription of neuronal genes.
May interact with GABAergic and glutamatergic systems according to transcriptomic studies.
Demonstrates stability in vitro due to the Pro-Gly-Pro motif, enhancing peptide bioavailability in CNS tissue models.
Research Applications
Semax is primarily utilized in neurogenomic, behavioral neuroscience, and molecular physiology research. Laboratory use cases include:
Gene-expression profiling of neurotrophic pathways (BDNF, NGF, CREB).
Investigation of neuroprotective and oxidative-stress responses in cell and rodent models.
Study of peptide signaling cross-talk between neurotransmitter and trophic-factor systems.
Storage & Handling
Store at 4 °C in a dry, light-protected environment for medium-term storage. Reconstitute with sterile, bacteriostatic solvent immediately before use. Proper storage maintains peptide integrity. Lyophilized Semax can be stored at 4 °C for months, while reconstituted Semax needs to be used within 4-7 days while stored at 4 °C.
Intended Use and Compliance
All peptide products from Peptide Systems are supplied for laboratory and scientific research use only. They are not FDA-approved and not intended for human or veterinary use. Purchase implies acceptance of our full Terms and Conditions outlining permitted research applications.
References & Further Reading
Semax ACTH (4-7) analogs and neurotrophic activity - https://pubmed.ncbi.nlm.nih.gov/16362768/
Semax-induced BDNF expression in cortex and hippocampus - https://pubmed.ncbi.nlm.nih.gov/19662538/
Gene-expression modulation by Semax in neural tissue - https://pmc.ncbi.nlm.nih.gov/articles/PMC3987924/
Semax and neuronal network dynamics - https://pubmed.ncbi.nlm.nih.gov/30225715/
Semax
Buy 5 vials get 16% off
CERTIFIED by 3rd party, US registered labs with ISO 17025:2017 certification
- Certified sterile.
- Certified free of microbial contaminants (endotoxin, LPS, LAL).
- Certified free of chemical contaminants (TFA, IEX).
- Certified peptide identity (HPLC, LC-MS).
- Certified >99% pure (HPLC).
