TB-500: The Research Behind This Popular Peptide
Oct 8, 2024
1 min read
Written by Johnathon Anderson, Ph.D., a research scientist, and Associate Professor at the University of California Davis School of Medicine
What is TB-500?
TB-500 is a peptide derived from thymosin beta-4 (Tβ4). (1)(2)
Is TB-500 Different Than Thymosin Beta 4?
TB-500 is a functional fragment of the thymosin beta-4 (Tβ4) peptide. (3) Tβ4 is a naturally occurring protein that has sparked immense scientific interest. Tβ4 has over 900 scientific, peer-reviewed publications exploring its signaling pathways.
Tβ4 has been the subject of more research than TB-500, since it was discovered first, back in 1970. (7) Tβ4 is present in many tissues of the body, including the thymus, brain, liver, kidney, testis, myocardium, and immune cells. (8) TB-500 is thought to possess many of the properties of Tβ4. Tβ4 has been shown to facilitate angiogenesis (9) and neurogenesis (10), with potent leukocyte modulating properties (11-14).
These wide-ranging properties indicate that Tβ4, and therefore potentially TB-500, may hold promise for the development of novel approaches to address a variety of indications.
References
1] https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.1402
2] https://www.theguardian.com/sport/blog/2015/mar/09/circ-report-cycling-doping
3] https://www.sciencedirect.com/science/article/pii/S1570023224000412?via%3Dihub
4] https://www.sciencedirect.com/science/article/pii/S0022202X15405950
5] https://pubmed.ncbi.nlm.nih.gov/27450736/
8] https://pubmed.ncbi.nlm.nih.gov/6954532/
9] https://pubmed.ncbi.nlm.nih.gov/28440414/
10] https://pubmed.ncbi.nlm.nih.gov/26363149/
11] https://pubmed.ncbi.nlm.nih.gov/19782721/
12] https://pubmed.ncbi.nlm.nih.gov/28245754/
13] https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06752.x
Oct 8, 2024
1 min read
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